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Leishmaniasis parasites evade death by exploiting the immune response to sand fly bites




Cutaneous leishmaniasis, a disease characterized by painful skin ulcers, occurs when the parasite Leishmania major, or a related species, is transmitted to a mammalian host by the bite of an infected sand fly. (2008-08-15)


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Human stem cells help brain-impaired mice
Injecting human stem cells into the brains of mice helped them recover almost fully from a neurological condition similar to a group of childhood diseases in people, researchers said.
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Rising energy, food prices major threats to wetlands as farmers eye new areas for crops
Critical food shortages and growing demand for bio-fuels and hydro-electricity due to high fossil fuel prices rank among the greatest threats today to the preservation of precious wetlands worldwide as farmers and developers look for new areas for agriculture, energy crop plantations and hydro dams. (2008-07-28)
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How Plants Fine Tune Their Natural Chemical Defenses
Even closely related plants produce their own natural chemical cocktails, each set uniquely adapted to the individual plant's specific habitat. Comparing antifungals produced by tobacco and henbane, researchers have discovered that only a few mutations in a key enzyme are enough to shift the whole output to an entirely new product mixture.
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what kind of a pest is this one.
What kind of bug is this. how do i get rid of it. i get 2 daily in my basement. is this bug dangerous. http://img329.imageshack.us/my.php?image=img0941mw7.jpg http://img112.imageshack.us/my.php?image=img0939dh8.jpg http://img378.imageshack.us/my.php?...
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Global identification of bursicon-regulated genes in drosophila melanogaster
Background: Bursicon is a heterodimer neuropeptide responsible for regulating cuticle sclerotization and wing expansion in several insect species. Recent studies indicate that the action of bursicon is mediated by a specific G protein-coupled receptor DLGR2 and the cAMP/PKA signaling pathway. However, little is known regarding the genes that are regulated by bursicon. The identification of bursicon-regulated genes is the focus of this investigation. Results: We used DNA microarray analysis to identify bursicon-regulated genes in neck-ligated flies (Drosophila melanogaster) that received recombinant bursicon (r-bursicon). Fifty four genes were found to be regulated by bursicon 1 h post r-bursicon injection, 52 being up-regulated and 2 down-regulated while 33 genes were influenced by r-bursicon 3 h post-injection (24 up-regulated and 9 down-regulated genes). Analysis of these genes by inference from the fly database (http://flybase.bio.indiana.edu) revealed that these genes encode proteins with diverse functions, including cell signaling, gene transcription, DNA/RNA binding, ion trafficking, proteolysis-peptidolysis, metabolism, cytoskeleton formation, immune response and cell-adhesion. Twenty eight genes randomly selected from the microarray-identified list were verified by real time PCR (qPCR) which supported the microarray data. Temporal response studies of 13 identified and verified genes by qPCR revealed that the temporal expression patterns of these genes are consistent with the microarray data. Conclusions: Using r-bursicon, we identified 87 genes that are regulated by bursicon, 30 of which have no previously known function. Most importantly, all genes randomly selected from the microarray-identified list were verified by real time PCR. Temporal analysis of 13 verified genes revealed that the expression of these genes was indeed induced by bursicon and correlated well with the cuticle sclerotization process. The composite data suggest that these genes play important roles in regulating the cuticle sclerotization and wing expansion processes. The data obtained here will form the basis for future studies aimed at elucidating the exact mechanisms upstream from the secretion of bursicon and its binding to target cells. (Source: BMC Genomics - Latest articles)
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Extensive myocardial infiltration by hemopoietic precursors in a patient with myelodysplastic syndrome
No abstract available (Source: BMC Blood Disorders)
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